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Collectively, these findings underscore the complexity of treating stress and sleep disorders, highlighting the variable effectiveness of treatments like GABA, DSIP-CBBBP, DSIP, and CBBBP alone in modulating key biochemical biomarkers

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Less obvious is the likelihood that AT 1 receptor blockade results in accumulating levels of AngII that are converted to AngIII and then to AngIV

This Recommendation is based on results of three observational studies that used high-pressure (e.g., systolic blood pressure, mean arterial pressure) and/or long duration (e.g., repeated intervals of 30 minutes, 3 hours continuously)