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Advanced platforms, such as two-dimensional gas chromatography (2D-GC) and two-dimensional high-performance liquid chromatography (2D-HPLC), offer greater sensitivity, separation, and sample preservation, but at the expense of high costs and technical complexity, which can limit their application in large-scale or translational studies (111113)

Additionally, research suggests that GLP-1 agonists may also influence central appetite control mechanisms in the brain

The primary adverse events were gastrointestinal in nature and mostly mild to moderate