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Again, this could be completely prevented by DPP-4 inhibition with valine pyrrolidide, confirming that cleavage by DPP-4 was the key initial step in GLP-1 degradation, and that other enzymatic pathways played a limited role (25)
It has been reported that GLP-1 RA reduces tau phosphorylation through Akt and GSK-3, a pathway related to insulin signaling, which also confirmed that insulin resistance is the key to tau phosphorylation
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They require occasional glucose monitoring, depending on severity
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