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A pilot RDP study with 37 patients with joint cartilage damage in the knee from primary osteoarthritis showed that the intake of 150 mg Pycnogenol per day for three months led to relieved joint discomfort, with a significant reduction of 43% in self-reported discomfort, 35% in stiffness and 52% in physical function compared to baseline while placebo controls showed no significant changes (40)
The lymphocyte co-stimulatory cascade was identified as the underlying molecular pathway and was blocked at several points with monoclonal antibodies, pointing towards novel therapeutic approaches, some of which are now in clinical trials
However, changes in skin clarity tend to develop gradually because systemic balance takes time
10.1038/sigtrans.2017.23 33
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