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Moreover, in the ileum and colon, active GLP-1 contents were actually 2- and 1.5-fold, respectively, higher than the stomach active GLP-1 content (Fig
Importantly, this only happens when blood sugar is high, minimizing the risk of hypoglycemia (low blood sugar)
More serious gastrointestinal complications, whilst rare, include acute pancreatitis and gallbladder disease (cholecystitis, cholelithiasis)
In the meta-analysis, SGLT2 inhibitors significantly reduced major adverse cardiovascular events (MACE), hospitalization for heart failure (HF) plus CV death, and progression of CKD by 11%, 23% and 33%, respectively, compared to placebo
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