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doi:10.1056/NEJMoa2107519 Wang W, et al

Amylin is a peptide hormone co-secreted with insulin from pancreatic beta cells after eating

All FDA-approved versions of semaglutide (Wegovy, Ozempic, and Rybelsus) are prescription-only medications

Tirzepatide's added GIP activity is thought to drive the larger effect on top of the shared GLP-1 pathway though weight loss is only one part of the picture, and semaglutide still has the longer cardiovascular-outcomes track record (more on that below)