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Regarding liver and kidney damage in MTX treatment, Bedoui stated that MTX hepatotoxicity may occur due to the depletion of folate reserves and MTX-polyglutamate formation in the liver (Reference Bedoui, Guillot and Slambarom41)
In a retrospective study of the postoperative course of 81 patients with adrenocorticotropic hormone independent Cushing syndrome, glucocorticoid withdrawal syndrome was most common when the 8 am serum cortisol level 24 hours after the last glucocorticoid dose was less than 5 g/dL, whereas no withdrawal symptoms were reported when it was higher than 10 g/dL
Zhong Z, Zhang C, Ni S, Ma M, Zhang X, Sang W, et al
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