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HGF/c-Met and the RAS/MAPK signaling pathway As mentioned above, the RAS/MAPK pathway is also considered a downstream effector of HGF/c-Met signals, among other signal transduction pathways [86, 121]

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[7] Active site [edit] The two copper atoms within the active site of tyrosinase enzymes interact with dioxygen to form a highly reactive chemical intermediate that then oxidizes the substrate