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The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination
Not having enough can cause tiredness, brain issues, and big red blood cells
They reduce appetite, improve blood sugar control, and enhance metabolic health
In mice, weight loss happened with no change in food intake at all, so the animal data points to altered fat metabolism rather than appetite suppression
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