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One approach, he said, involves packaging peptides inside nanoparticles, microscopic carriers designed to protect the drugs and help deliver them more effectively to their intended targets
PMID: 16634527
Short NJ, Garcia-Manero G, Naqvi K, Kornblau SM, Abhishek M, Konopleva M, DiNardo CD, Takahashi K, Alvarado Y, Ohanian M, Estrov Z, Bose P, Andreeff M , Islan R, Dong X, Cortes JE, Kantarjian HM, Jabbour EJ
For example, genetic deletion of AMPK in mouse models of leukemia resulted in tumor cell death and dramatically improved mouse survival 9,10,11
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