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The administration of GLP-1RA or exendin-4 to rats fed a high-fat diet resulted in an increase in the OPG/RANKL ratio and a reduction in the degree of bone loss

Quick Answer: Flu-like symptoms are not listed as common adverse effects in FDA prescribing information for tirzepatide, though some patients report fatigue and systemic symptoms that may be related to dehydration or metabolic adaptation

A possible role of vitamin D supplementation in promoting cancer progression has also been reported, although the evidence is limited and primarily derived from observational associations