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While traditional B12 shots have long been the go-to option for people with deficiencies or those seeking an energy boost, IV therapy has gained popularity as a comprehensive approach that delivers B12 alongside other beneficial vitamins and minerals
Animal research used weight-based dosing roughly in the range of 10 mcg per kg, which for a 80 kg human would be approximately 800 mcg per day, though extrapolation from rodent to human dose is not straightforward and this is not a clinical recommendation
This process consumes cellular methyl donors and, critically, prevents nicotinamide from being recycled into NAD+
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