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Use caution if you have autoimmune disease, bleeding disorders, active infection, cancer history, or if you take anticoagulants, immunosuppressants, or systemic steroids

Applying vitamin C to your skin may reduce hyperpigmentation by interfering with an enzyme called tyrosinase, which is responsible for the production of melanin, a natural skin pigment ( Moreover, vitamin C acts as a brightening agent and can reduce the appearance of darkened spots without changing the natural color of your skin ( Some human studies that combine topical vitamin C with iontophoresis an electrical gradient applied to the skin found significant reductions in hyperpigmentation ( Though this method is promising, iontophoresis increases vitamin C absorption into your skin, meaning that topical application of vitamin C alone may not yield the same results ( Furthermore, most related studies use vitamin C in combination with other anti-hyperpigmentation ingredients like alpha-hydroxy acids, making it hard to determine the specific effects of the vitamin

4 Secondary parkinsonism , due to other causes or nonidiopathic parkinsonism, has a different etiology and pathology than does PD

IHC staining of tumor microarrays, brain tissues, and xenografted tumors was carried out by Wuhan ServiceBio Technology Co., Ltd