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For a patient-facing medical summary, review the Mayo Clinic oral semaglutide overview
An increased risk of amputations was reported in the CANVAS Program trial but has not been demonstrated in any other clinical trial nor was there any signal of this issue in a meta-analysis involving 57,713 participants [54]
This minimizes waste during the low-dose ramp and maximizes value during the high-consumption maintenance period
Some maintain full results at 2.5 mg weekly
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