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However, in the posterior cortex, CAT activity was reduced in the VPA+LipRSV group compared to the VPA group, indicating that LipRSV treatment may have negatively modulated the enzymes expression or activity, either by attenuating oxidative stress and thus reducing enzymatic defense needs, or through a possible pro-oxidant effect dependent on the region and experimental conditions

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Additional ingredients like caffeine and rosemary extract provide complementary benefits through different mechanisms

Nutrient sensing occurs in the stomach and duodenum and is signaled to the brain through neural pathways, but especially through the release of gut peptides, which was shown in some studies to be correlated with symptoms in FD and gastroparesis