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Therefore, we could have chosen any percentage within the 40% to 100% range to represent the average estradiol in females
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Because the maternal serum holo-hCG and free hCG- levels are markedly elevated when the fetus has trisomy 21, hCG is considered the most sensitive individual marker for fetal Down syndrome.92 Higher than usual maternal serum proportions of nicked hCG and free subunit, and core fragment in maternal urine, also are associated with Down syndrome pregnancies, but there does not appear to be any benefit to using free hCG- versus holo-hCG in MMS.93, 94, 95 Integration of other hCG molecules, such as urinary hyperglycosylated hCG, novel maternal serum markers (i.e
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