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Some of the signs and symptoms of this deficiency can include anemia, the buildup of too much acid in the body (metabolic acidosis), frequent infections and symptoms caused by problems in the brain (including seizures, intellectual disability and loss of coordination)

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Notably, a reduction in the potassium channel Kir4.1 and an increase in AQP4 in the astrocyte end-feet of ALS model rats indicate challenges in maintaining water and potassium balance, further compromising BBB stability [247]

This is perhaps the most actionable finding in the entire side effect dataset