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Verdict: Limited evidence overall DSIP has some preliminary human sleep data, but most broader claims remain unproven, and safety uncertainty is substantial [24][14]

In a study aimed to establish tirzepatde influence on lipid profile [27], at 26 weeks the three dosages of the drug decreased the levels of apoB, apoC-III levels, large triglyceride-rich lipoprotein particles, and small low-density lipoprotein particles compared with both placebo and dulaglutide

Lastly, the limited evidence on the effects of GLP-1 RAs on key pathognomonic proteins, A and -synuclein, weakens the scientific basis for considering GLP-1 RAs as major game-changers for neurodegenerative diseases

Black JW, Leff P