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Meta-analyses show that semaglutide increases the likelihood of discontinuing treatment (relative risk 1.67, 95% CI 1.27-2.21), primarily due to gastrointestinal adverse events

While it tends to be more affordable than the brand-name, FDA-approved drugs, compounded semaglutide is not FDA-approved and is not usually covered by health insurance

However, until now, robust evidence from randomized clinical trials has been limited

En ensayos clnicos recientes, orforglipron ha demostrado reducciones en la hemoglobina glucosilada (HbA1c) de hasta 1.7% y una prdida de peso corporal de hasta 14.7% en adultos con obesidad, cifras que lo colocan a la par de los tratamientos inyectables ms potentes