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In the gas-fluid organoids derived from colon cancer, the efficacy of 5-FU, irinotecan, and oxaliplatin is enhanced by hedgehog signaling inhibitors through the suppression of GLI-1 expression, thereby reducing drug resistance [234]
Overexpression of glutathione S-transferase pi enhances the adduct formation of [PMID: 10630679] Laboratory literature summary: Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in research subjects oncology
Its structure allows researchers to focus on specific pathway behavior, receptor interaction, and cellular responses under controlled experimental conditions
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