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"In any case, we believe that the observed effect reflects the mechanism of action inherent in targeting the GLP-1 receptor." Braca said they decided to investigate the potential impact of GLP-1 on migraine based on previous work by their research team, which suspected that impaired intracranial pressure control plays a role in the pathophysiology of migraine
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Although the specific mechanisms are not understood, reports indicate that semaglutide can modulate inflammatory processes by reducing levels of interleukin-6 (IL-6), tumor necrosis factor- (TNF-) and high-sensitivity C-reactive protein (hsCRP)
However, these claims are only a few case reports and small studies
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