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J Orthopaed Surg Res (2020) 15(1):142

Both peptides show favorable safety profiles in preclinical studies

Unpredictable Allergic Reactions and Rashes: By blocking calcium influx into mast cells and preventing degranulation, EGCg acts as a natural mast cell stabilizer, reducing the systemic release of histamine that triggers dermatological and allergic flares

Systemic allergic signs that require emergency medical attention include widespread hives across multiple body areas, swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, rapid heartbeat or feeling faint, and dizziness or confusion