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When modified by NAPQI, Keap1 releases Nrf2, enabling its translocation into the nucleus, where it binds to antioxidant response elements in DNA and promotes transcription of genes encoding various antioxidant enzymes
Future studies should also use therapeutic models in which remogliflozin therapy starts post-establishment of liver fibrosis to more accurately evaluate its clinical significance as a prospective treatment
doi: 10.3389/fimmu.2021.720109 146 KobayashiE
inclusion does not imply endorsement of any therapeutic use.
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