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The trial adequately powered to detect a 3-4 kg difference with the dosing regimen used (PMID: 23714218)
However, there are varying results when it comes to weight loss, as some individuals see slower progress depending on their overall diet and exercise regimen
By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways
By improving cellular energy production and promoting fat burning, it may help reduce the visible signs of aging related to metabolic slowdown
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