glp-1 versus glp-2 Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial GLP-1 vs GLP-2: The Key

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The mean total of the diabetic group with 3 studies was 6.31 AU and the mean total in the healthy control was 1.0 AU, which indicated an increase of 531% between the two treatment groups

These findings suggest that, even when key physicochemical properties are optimized, uniform brain distribution is not guaranteed, potentially contributing to region-specific therapeutic responses

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