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The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

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While these medications had impactful weight loss outcomes, with mean weight reduction in trials ranging from 7 to 10% [3,4,5], they lacked substantial evidence of improvement in cardiovascular outcomes

Ipamorelin works by mimicking the action of ghrelin, a naturally occurring hormone that stimulates GH secretion