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Although ROS can promote IL-1 and IL-10 2,3,4 , its precise role remains debated, with recent work highlighting mitochondrial ATP as a driver of NLRP3-dependent IL-1 release 5,6

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Locked by the conserved disulfide bond (C46-C71) with the N-terminal -helix, 1 strand (residues 61 to 77) of GLP-1R ECD also shifted towards ECL1 by 9.3 (measured at the C of E68)

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