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Ethical approval and consent to participate The study was conducted in accordance with the Declaration of Helsinki, and the animal study protocol was approved by the Institutional Review Board (or Ethics Committee) of Van Yznc Yl University (2023/0733,) Animal Experiments and Local Ethics Committee (2023/0733)

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Icariin prevents extracellular matrix accumulation and ameliorates experimental diabetic kidney disease by inhibiting oxidative stress via Gper mediated p62-dependent keap1 degradation and nrf2 activation