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Vagal mediation of GLP-1s effects on food intake and glycemia

This gradual approach allows your body to adapt to the medication and helps minimize gastrointestinal side effects

Tirzepatide is a newer drug, so there is less data available on it Tirzepatide is a newer drug that was FDA approved in 2022 that promotes weight-loss via GLP-1 receptor and GIP receptor agonism

Maintain adequate calcium (1,000-1,200 mg daily) and vitamin D intake, consume sufficient protein (1.0-1.2 g/kg body weight), perform regular weight-bearing and resistance exercise, and discuss appropriate monitoring with your healthcare provider based on your individual risk factors