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Standardization of clinical trial designs and validation of noninvasive procedures will greatly accelerate the pace of discovering effective therapies
Tirzepatide is the current evidence leader
Ceruloplasmin (CP) is a ferroxidase that is mainly found in a GPI-anchored form on astrocytes, converting toxic Fe 2+ to non-toxic Fe 3+ , physically associating with FPN1 to facilitate iron efflux from central nervous system cells, and inhibiting Fe 2+ -mediated lipid peroxidation by reducing the presence of highly reactive Fe 2+ (54, 55)
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