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Epub 2021 Nov 16
Chasing a substance no one was even sure existed
IschemiaReperfusion or Hypoxic Injury Models In research models of ischemic insult (e.g., engineered tissue constructs under oxygen deprivation), the blend may be relevant to evaluations of its potential to rescue microvasculature, reduce necrosis spread, or promote regenerative infiltration when reperfusion is restored
Specifically, IgGs obtained from the CSF of patients with anti-GAD65Ab-associated CA depressed GABA release in cerebellar brain slices [77, 78, 82, 85], and their intracerebellar injection interfered with cerebellar control of the motor cortex and resulted in ataxic gait in rats [79]
