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People who might become pregnant should use effective contraception while taking any medication containing topiramate
Both NF-B signaling and mtROS promote NLPR3 inflammasome assembly, a key driver of neuroinflammation that leads to cleavage of precursor cytokines into biologically active pro-inflammatory cytokines, IL-1 and IL-18 ( In contrast to pro-inflammatory microglial activation, M2 microglia activation increases anti-inflammatory cytokine production, promoting neuroprotection through tissue repair and debris clearance
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Most people notice an increase in appetite as hunger signals return to normal
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