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Approved in January 2010 as Victoza for type 2 diabetes, liraglutide introduced once daily dosing and demonstrated cardiovascular benefits
To stop signal transduction, Kdm2a/b competes with TCF/LEF for -catenin binding and removes methyl markers from -catenin, which is subsequently degraded via ubiquitination
It acts as a potent reducing agent, donating electrons to neutralize free radicals, those unstable molecules that wreak havoc on cellular structures [1]
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