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However, AD pathology extends beyond amyloid and tau, encompassing a multifaceted array of pathophysiological mechanisms, including chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, impaired proteostasis (the homeostasis of protein folding, stability, and degradation), calcium dysregulation, excitotoxicity, and breakdown of the blood-brain barrier (BBB) [16, 17]
They found that when they eliminated TRPA1 and repeated the hot plate test, paracetamol had no effect against pain
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