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Some of these adverse effects reported were Toxic Epidermal Necrolysis (a rare but life-threatening skin condition characterized by painful blisters and large areas of skin peeling), air embolism, thyroid dysfunction, and liver, kidney, and neurologic toxicity (The dark side of skin lightening- PubMed) With the proliferation of med-spas in an unregulated fashion, there is a risk of inadequately trained or untrained people giving IV injections in a non-sterile way, which can lead to sepsis and transmission of infections like HIV and hepatitis

The body preferentially uses adipose stores rather than breaking down muscle protein for fuel

For pediatric cases (often coded under P54.1 for neonates or the standard K62.5 for older children), the documentation must clearly differentiate between "functional" causes like constipation-induced fissures and "pathological" causes like Meckels diverticulum

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