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Clinical evidence suggests that slower dose escalation, consistent meal timing, and adequate hydration significantly reduce nausea and vomiting incidence, though genetic and biomarker factors also play a role in determining individual tolerability thresholds

Its really important to understand what the FDA is doing, who the makeup of the FDA committee members are, what their backgrounds are, what their potential, if any, financial conflicts of interest are, and what their ultimate goals are as individuals and as a committee, because there may be some conflicts with respect to some of these products, Frank said

Adjust volume as needed for other concentrations

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