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Firstly, the synthesis of GSH-depleted multicomponent nanomedicines is so time-consuming that it still faces a huge technological gap from laboratory preparation to industrial production ( 5 Conclusion and outlook Cancer cells show overexpressed GSH that may maintain redox homeostasis to protect cells from oxidative damage, as well as reduce the chemotherapeutic agent-induced toxification

Rao SV, ODonoghue ML, Ruel M, et al

The duration of the included articles ranged from 5 to 48 weeks, and the sample size ranged from 10 to 148 cases

The efficacy of the vial can be compromised by 20%, 50% or more due to one large temperature excursion