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In PIONEER-2, oral semaglutide reduced CRP, whereas empagliflozin did not, despite similar weight loss

The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate

Retatrutide's diabetes relevance comes from its incretin and glucagon receptor profile

Skin Pigmentation: Successfully induces significant and long-lasting skin darkening (tanning) following subcutaneous administration, peaking about a week after treatment completion