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Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

Conversely, some self-injected drugs might have a medical benefit component (e.g

Phase 2 and Phase 3 data show favorable changes in cardiovascular risk factors, but direct evidence of event reduction is pending