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It belongs to a broader class of peptide therapeutics that are reshaping how longevity medicine thinks about tissue maintenance, cellular signaling, and the biology of repair

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10.1186/s12943-020-01258-7 Summary Keywords ulcerative colitis, GHK-Cu, SIRT1/STAT3 pathway, co-culture system, network pharmacology, molecular docking Citation Mao S, Huang J, Li J, Sun F, Zhang Q, Cheng Q, Zeng W, Lei D, Wang S and Yao J (2025) Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

TB-500 promotes angiogenesis systemically, potentially creating new microvascular networks in the tissue surrounding the disc