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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

Yet a nasal spray product will typically arrive prepared in a metered spray bottle for researchers to use right away

In 1972 I was told I had two years to live unless I ate raw liver three times a day or B12 injections every month - I chose to have the injections 46 years on

[13] There have also been rare reports of high-dose vitamin B (as in injectable form) precipitating skin outbreaks such as acne or rosacea in susceptible persons