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To attain the health benefits conferred by GLP-1s, it is critical that people prescribed GLP-1s continue to take them at least long enough to realize clinical success, and preferably longer to avoid possible weight rebound once they come off the medications
73 The mechanisms responsible for this risk may be related to cytokines that increase endothelial activation and potentially make atheromatous plaques unstable
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Routine measurement of serum calcitonin or thyroid ultrasound surveillance is not recommended for the general population of patients prescribed tirzepatide, as these screening approaches have poor positive predictive value and may lead to unnecessary interventions in patients with benign findings
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