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Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants
Schauer PR, Bhatt DL, Kirwan JP, et al
74 : 2133 Mallinger AG, Hanin I
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