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The abdomen is generally the least painful site for most people
Several factors may influence individual susceptibility to nausea, though specific risk factors for tirzepatide-related nausea have not been definitively established in clinical trials
The FDA-approved escalation protocol starts at 2.5 mg weekly, then increases by 2.5 mg increments every four weeks until reaching a therapeutic dose between 5 mg and 15 mg per week
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