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FDA no longer needs to require animal tests before human drug trials
The following standards were set
In the blood, about 80% of cobalamin is bound to haptocorrin, forming holohaptocorrin, a complex that has a dual function: (1) holohaptocorrin conveys cobalamin to the liver, where it taken up through endocytosis (mediated by asialoglycoprotein receptor, ASGPR)
All research cited on this page is from preclinical animal studies
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