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A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented
Open 7 , e2416775 (2024)
Cardiovascular benefits of GLP-1 The SELECT trial demonstrated that GLP-1 therapy rapidly reduces heart attacks and strokes. These cardiovascular benefits have long been hinted at in diabetes trials, but the magnitude observed in SELECT surprised even seasoned cardiologists
Acknowledgements We are grateful to Jens Brning for providing the IR flox/flox mice
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