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Effect of PA on oxidative stress markers The APAP treatment induced a statistically significant increase in MDA level and a decrease in GSH level in mice liver ( p 0.001), while PA produced an improvement in the oxidative stress state by decreasing the MDA level and increasing the GSH level in the APAP + PA group when compared to the APAP group ( p 0.001) (Table 3)

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Alternatively, serine can be converted to glycine for glutathione synthesis [48,49]

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