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New England Journal of Medicine, Aug 14, 2025
It is a 15-amino acid peptide sequence derived from a naturally occurring protein found in human gastric juice
Unlike vitamins or minerals, peptides are large, fragile molecules typically degraded in the digestive system before they can exert systemic effects
The construct incorporates an N-terminal nona-D-arginine (D-Arg)9 cell-penetrating tag fused to a segment derived from the FOXO4-p53 interaction domain, giving the peptide a strongly cationic overall character driven by its multiple arginine and lysine residues, along with a single tryptophan that supports UV monitoring at 280 nm during analytical workflows
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