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Mounjaro (tirzepatide) A newer medication that combines two hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), Tirzepatide (Mounjaro/Zepbound): Dual GIP/GLP-1 agonist
Glucagon-like peptide-1 receptor agonists and risk of bone fracture in patients with type 2 diabetes: A meta-analysis of randomised controlled trials
GLP-1RAs, such as exendin-4 and liraglutide, can reduce neuroinflammation caused by microglia by encouraging a conversion from the pro-inflammatory M1 subtype towards the anti-inflammatory M2 phenotype
38 Thus, in this manner exogenous or endogenous sources of ROS can initiate or promote mitochondrial dysfunction and damage, especially if the mitochondria are genetically susceptible to dysfunction
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