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Moreover, individuals who are malnourished, have cancer, are elderly, pregnant, or are alcoholics are also at higher risk in suffering the lack of vitamin B12

For instance, hydration benefits may be felt for a few days, but the enduring energy may last for a few weeks

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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss